Application of Pharmacovigilance Methods in Occupational Health Surveillance: Comparison of Seven Disproportionality Metrics
Identifieur interne : 000638 ( Main/Exploration ); précédent : 000637; suivant : 000639Application of Pharmacovigilance Methods in Occupational Health Surveillance: Comparison of Seven Disproportionality Metrics
Auteurs : Vincent Bonneterre [France] ; Dominique Joseph Bicout [France] ; Regis De Gaudemaris [France]Source :
- Safety and Health at Work [ 2093-7911 ] ; 2012.
Abstract
The French National Occupational Diseases Surveillance and Prevention Network (RNV3P) is a French network of occupational disease specialists, which collects, in standardised coded reports, all cases where a physician of any specialty, referred a patient to a university occupational disease centre, to establish the relation between the disease observed and occupational exposures, independently of statutory considerations related to compensation. The objective is to compare the relevance of disproportionality measures, widely used in pharmacovigilance, for the detection of potentially new disease × exposure associations in RNV3P database (by analogy with the detection of potentially new health event × drug associations in the spontaneous reporting databases from pharmacovigilance).
2001-2009 data from RNV3P are used (81,132 observations leading to 11,627 disease × exposure associations). The structure of RNV3P database is compared with the ones of pharmacovigilance databases. Seven disproportionality metrics are tested and their results, notably in terms of ranking the disease × exposure associations, are compared.
RNV3P and pharmacovigilance databases showed similar structure. Frequentist methods (proportional reporting ratio [PRR], reporting odds ratio [ROR]) and a Bayesian one (known as BCPNN for "Bayesian Confidence Propagation Neural Network") show a rather similar behaviour on our data, conversely to other methods (as Poisson). Finally the PRR method was chosen, because more complex methods did not show a greater value with the RNV3P data. Accordingly, a procedure for detecting signals with PRR method, automatic triage for exclusion of associations already known, and then investigating these signals is suggested.
This procedure may be seen as a first step of hypothesis generation before launching epidemiological and/or experimental studies.
Url:
DOI: 10.5491/SHAW.2012.3.2.92
PubMed: 22993712
PubMed Central: 3440466
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000229
- to stream Pmc, to step Curation: 000227
- to stream Pmc, to step Checkpoint: 000090
- to stream Ncbi, to step Merge: 000326
- to stream Ncbi, to step Curation: 000326
- to stream Ncbi, to step Checkpoint: 000326
- to stream Main, to step Merge: 000638
- to stream Main, to step Curation: 000638
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Application of Pharmacovigilance Methods in Occupational Health Surveillance: Comparison of Seven Disproportionality Metrics</title><author><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">The French National Occupational Diseases Surveillance and Prevention Network (RNV3P), France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>The French National Occupational Diseases Surveillance and Prevention Network (RNV3P)</wicri:regionArea></affiliation></author><author><name sortKey="Bicout, Dominique Joseph" sort="Bicout, Dominique Joseph" uniqKey="Bicout D" first="Dominique Joseph" last="Bicout">Dominique Joseph Bicout</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="De Gaudemaris, Regis" sort="De Gaudemaris, Regis" uniqKey="De Gaudemaris R" first="Regis" last="De Gaudemaris">Regis De Gaudemaris</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">The French National Occupational Diseases Surveillance and Prevention Network (RNV3P), France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>The French National Occupational Diseases Surveillance and Prevention Network (RNV3P)</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22993712</idno><idno type="pmc">3440466</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440466</idno><idno type="RBID">PMC:3440466</idno><idno type="doi">10.5491/SHAW.2012.3.2.92</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000229</idno><idno type="wicri:Area/Pmc/Curation">000227</idno><idno type="wicri:Area/Pmc/Checkpoint">000090</idno><idno type="wicri:Area/Ncbi/Merge">000326</idno><idno type="wicri:Area/Ncbi/Curation">000326</idno><idno type="wicri:Area/Ncbi/Checkpoint">000326</idno><idno type="wicri:doubleKey">2093-7911:2012:Bonneterre V:application:of:pharmacovigilance</idno><idno type="wicri:Area/Main/Merge">000638</idno><idno type="wicri:Area/Main/Curation">000638</idno><idno type="wicri:Area/Main/Exploration">000638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Application of Pharmacovigilance Methods in Occupational Health Surveillance: Comparison of Seven Disproportionality Metrics</title><author><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">The French National Occupational Diseases Surveillance and Prevention Network (RNV3P), France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>The French National Occupational Diseases Surveillance and Prevention Network (RNV3P)</wicri:regionArea></affiliation></author><author><name sortKey="Bicout, Dominique Joseph" sort="Bicout, Dominique Joseph" uniqKey="Bicout D" first="Dominique Joseph" last="Bicout">Dominique Joseph Bicout</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="De Gaudemaris, Regis" sort="De Gaudemaris, Regis" uniqKey="De Gaudemaris R" first="Regis" last="De Gaudemaris">Regis De Gaudemaris</name><affiliation wicri:level="1"><nlm:aff id="A1">UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525 (EPSP team- Environment and Health Prediction in Populations), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Occupational and Environmental Diseases Centre, Grenoble Teaching Hospital (CHU Grenoble), Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">The French National Occupational Diseases Surveillance and Prevention Network (RNV3P), France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>The French National Occupational Diseases Surveillance and Prevention Network (RNV3P)</wicri:regionArea></affiliation></author></analytic><series><title level="j">Safety and Health at Work</title><idno type="ISSN">2093-7911</idno><idno type="eISSN">2093-7997</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>The French National Occupational Diseases Surveillance and Prevention Network (RNV3P) is a French network of occupational disease specialists, which collects, in standardised coded reports, all cases where a physician of any specialty, referred a patient to a university occupational disease centre, to establish the relation between the disease observed and occupational exposures, independently of statutory considerations related to compensation. The objective is to compare the relevance of disproportionality measures, widely used in pharmacovigilance, for the detection of potentially new disease × exposure associations in RNV3P database (by analogy with the detection of potentially new health event × drug associations in the spontaneous reporting databases from pharmacovigilance).</p></sec><sec><title>Methods</title><p>2001-2009 data from RNV3P are used (81,132 observations leading to 11,627 disease × exposure associations). The structure of RNV3P database is compared with the ones of pharmacovigilance databases. Seven disproportionality metrics are tested and their results, notably in terms of ranking the disease × exposure associations, are compared.</p></sec><sec><title>Results</title><p>RNV3P and pharmacovigilance databases showed similar structure. Frequentist methods (proportional reporting ratio [PRR], reporting odds ratio [ROR]) and a Bayesian one (known as BCPNN for "Bayesian Confidence Propagation Neural Network") show a rather similar behaviour on our data, conversely to other methods (as Poisson). Finally the PRR method was chosen, because more complex methods did not show a greater value with the RNV3P data. Accordingly, a procedure for detecting signals with PRR method, automatic triage for exclusion of associations already known, and then investigating these signals is suggested.</p></sec><sec><title>Conclusion</title><p>This procedure may be seen as a first step of hypothesis generation before launching epidemiological and/or experimental studies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Carder, M" uniqKey="Carder M">M Carder</name></author><author><name sortKey="Mcnamee, R" uniqKey="Mcnamee R">R McNamee</name></author><author><name sortKey="Turner, S" uniqKey="Turner S">S Turner</name></author><author><name sortKey="Hussey, L" uniqKey="Hussey L">L Hussey</name></author><author><name sortKey="Money, A" uniqKey="Money A">A Money</name></author><author><name sortKey="Agius, R" uniqKey="Agius R">R Agius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussey, L" uniqKey="Hussey L">L Hussey</name></author><author><name sortKey="Turner, S" uniqKey="Turner S">S Turner</name></author><author><name sortKey="Thorley, K" uniqKey="Thorley K">K Thorley</name></author><author><name sortKey="Mcnamee, R" uniqKey="Mcnamee R">R McNamee</name></author><author><name sortKey="Agius, R" uniqKey="Agius R">R Agius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcnamee, R" uniqKey="Mcnamee R">R McNamee</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Hussey, L" uniqKey="Hussey L">L Hussey</name></author><author><name sortKey="Agius, R" uniqKey="Agius R">R Agius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stocks, Sj" uniqKey="Stocks S">SJ Stocks</name></author><author><name sortKey="Mcnamee, R" uniqKey="Mcnamee R">R McNamee</name></author><author><name sortKey="Carder, M" uniqKey="Carder M">M Carder</name></author><author><name sortKey="Agius, Rm" uniqKey="Agius R">RM Agius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author><author><name sortKey="Bicout, D" uniqKey="Bicout D">D Bicout</name></author><author><name sortKey="Bernardet, C" uniqKey="Bernardet C">C Bernardet</name></author><author><name sortKey="Dupas, D" uniqKey="Dupas D">D Dupas</name></author><author><name sortKey="De Claviere, C" uniqKey="De Claviere C">C de Clavière</name></author><author><name sortKey="De Gaudemaris, R" uniqKey="De Gaudemaris R">R de Gaudemaris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author><author><name sortKey="De Gaudemaris, R" uniqKey="De Gaudemaris R">R de Gaudemaris</name></author><author><name sortKey="Celse, M" uniqKey="Celse M">M Celse</name></author><author><name sortKey="Chamoux, A" uniqKey="Chamoux A">A Chamoux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author><author><name sortKey="Faisandier, L" uniqKey="Faisandier L">L Faisandier</name></author><author><name sortKey="Bicout, D" uniqKey="Bicout D">D Bicout</name></author><author><name sortKey="Bernardet, C" uniqKey="Bernardet C">C Bernardet</name></author><author><name sortKey="Piollat, J" uniqKey="Piollat J">J Piollat</name></author><author><name sortKey="Ameille, J" uniqKey="Ameille J">J Ameille</name></author><author><name sortKey="De Claviere, C" uniqKey="De Claviere C">C de Claviére</name></author><author><name sortKey="Aptel, M" uniqKey="Aptel M">M Aptel</name></author><author><name sortKey="Lasfargues, G" uniqKey="Lasfargues G">G Lasfargues</name></author><author><name sortKey="De Gaudemaris, R" uniqKey="De Gaudemaris R">R de Gaudemaris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, Wa" uniqKey="Watson W">WA Watson</name></author><author><name sortKey="Litovitz, Tl" uniqKey="Litovitz T">TL Litovitz</name></author><author><name sortKey="Belson, Mg" uniqKey="Belson M">MG Belson</name></author><author><name sortKey="Wolkin, Ab" uniqKey="Wolkin A">AB Wolkin</name></author><author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name></author><author><name sortKey="Schier, Jg" uniqKey="Schier J">JG Schier</name></author><author><name sortKey="Reid, Ne" uniqKey="Reid N">NE Reid</name></author><author><name sortKey="Kilbourne, E" uniqKey="Kilbourne E">E Kilbourne</name></author><author><name sortKey="Rubin, C" uniqKey="Rubin C">C Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henning, Kj" uniqKey="Henning K">KJ Henning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wagner, Mm" uniqKey="Wagner M">MM Wagner</name></author><author><name sortKey="Espino, J" uniqKey="Espino J">J Espino</name></author><author><name sortKey="Tsui, Fc" uniqKey="Tsui F">FC Tsui</name></author><author><name sortKey="Gesteland, P" uniqKey="Gesteland P">P Gesteland</name></author><author><name sortKey="Chapman, W" uniqKey="Chapman W">W Chapman</name></author><author><name sortKey="Ivanov, O" uniqKey="Ivanov O">O Ivanov</name></author><author><name sortKey="Moore, A" uniqKey="Moore A">A Moore</name></author><author><name sortKey="Wong, W" uniqKey="Wong W">W Wong</name></author><author><name sortKey="Dowling, J" uniqKey="Dowling J">J Dowling</name></author><author><name sortKey="Hutman, J" uniqKey="Hutman J">J Hutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindquist, M" uniqKey="Lindquist M">M Lindquist</name></author><author><name sortKey="Edwards, Ir" uniqKey="Edwards I">IR Edwards</name></author><author><name sortKey="Bate, A" uniqKey="Bate A">A Bate</name></author><author><name sortKey="Fucik, H" uniqKey="Fucik H">H Fucik</name></author><author><name sortKey="Nunes, Am" uniqKey="Nunes A">AM Nunes</name></author><author><name sortKey="St Hl, M" uniqKey="St Hl M">M Ståhl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Am" uniqKey="Wilson A">AM Wilson</name></author><author><name sortKey="Thabane, L" uniqKey="Thabane L">L Thabane</name></author><author><name sortKey="Holbrook, A" uniqKey="Holbrook A">A Holbrook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hauben, M" uniqKey="Hauben M">M Hauben</name></author><author><name sortKey="Bate, A" uniqKey="Bate A">A Bate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author><author><name sortKey="Bicout, Dj" uniqKey="Bicout D">DJ Bicout</name></author><author><name sortKey="Larabi, L" uniqKey="Larabi L">L Larabi</name></author><author><name sortKey="Bernardet, C" uniqKey="Bernardet C">C Bernardet</name></author><author><name sortKey="Maitre, A" uniqKey="Maitre A">A Maitre</name></author><author><name sortKey="Tubert Bitter, P" uniqKey="Tubert Bitter P">P Tubert-Bitter</name></author><author><name sortKey="De Gaudemaris, R" uniqKey="De Gaudemaris R">R de Gaudemaris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, E" uniqKey="Roux E">E Roux</name></author><author><name sortKey="Thiessard, F" uniqKey="Thiessard F">F Thiessard</name></author><author><name sortKey="Fourrier, A" uniqKey="Fourrier A">A Fourrier</name></author><author><name sortKey="Begaud, B" uniqKey="Begaud B">B Bégaud</name></author><author><name sortKey="Tubert Bitter, P" uniqKey="Tubert Bitter P">P Tubert-Bitter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Puijenbroek, Ep" uniqKey="Van Puijenbroek E">EP van Puijenbroek</name></author><author><name sortKey="Bate, A" uniqKey="Bate A">A Bate</name></author><author><name sortKey="Leufkens, Hg" uniqKey="Leufkens H">HG Leufkens</name></author><author><name sortKey="Lindquist, M" uniqKey="Lindquist M">M Lindquist</name></author><author><name sortKey="Orre, R" uniqKey="Orre R">R Orre</name></author><author><name sortKey="Egberts, Ac" uniqKey="Egberts A">AC Egberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szarfman, A" uniqKey="Szarfman A">A Szarfman</name></author><author><name sortKey="Machado, Sg" uniqKey="Machado S">SG Machado</name></author><author><name sortKey="O Neill, Rt" uniqKey="O Neill R">RT O'Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hauben, M" uniqKey="Hauben M">M Hauben</name></author><author><name sortKey="Reich, L" uniqKey="Reich L">L Reich</name></author><author><name sortKey="Chung, S" uniqKey="Chung S">S Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faisandier, L" uniqKey="Faisandier L">L Faisandier</name></author><author><name sortKey="Bonneterre, V" uniqKey="Bonneterre V">V Bonneterre</name></author><author><name sortKey="De Gaudemaris, R" uniqKey="De Gaudemaris R">R De Gaudemaris</name></author><author><name sortKey="Bicout, Dj" uniqKey="Bicout D">DJ Bicout</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><settlement><li>Grenoble</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name></noRegion><name sortKey="Bicout, Dominique Joseph" sort="Bicout, Dominique Joseph" uniqKey="Bicout D" first="Dominique Joseph" last="Bicout">Dominique Joseph Bicout</name><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><name sortKey="Bonneterre, Vincent" sort="Bonneterre, Vincent" uniqKey="Bonneterre V" first="Vincent" last="Bonneterre">Vincent Bonneterre</name><name sortKey="De Gaudemaris, Regis" sort="De Gaudemaris, Regis" uniqKey="De Gaudemaris R" first="Regis" last="De Gaudemaris">Regis De Gaudemaris</name><name sortKey="De Gaudemaris, Regis" sort="De Gaudemaris, Regis" uniqKey="De Gaudemaris R" first="Regis" last="De Gaudemaris">Regis De Gaudemaris</name><name sortKey="De Gaudemaris, Regis" sort="De Gaudemaris, Regis" uniqKey="De Gaudemaris R" first="Regis" last="De Gaudemaris">Regis De Gaudemaris</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000638 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000638 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3440466
|texte= Application of Pharmacovigilance Methods in Occupational Health Surveillance: Comparison of Seven Disproportionality Metrics
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22993712" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |